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SKU381189287
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air jordan 13 retro black\/true red-white

monolog/monolog

Sends your logs to files, sockets, inboxes, databases and various web services

89 593 232 9 787

Guzzle is a PHP HTTP client library

62 919 761 12 464

Assertions to validate method input/output with nice error messages.

44 543 909 2 835

Loads environment variables from `.env` to `getenv()`, `$_ENV` and `$_SERVER` automagically.

35 295 349 6 395

Twig, the flexible, fast, and secure template language for PHP

48 950 203 4 940

The most popular front-end framework for developing responsive, mobile first projects on the web.

3 012 837 123 285

CssToInlineStyles is a class that enables you to convert HTML-pages/files into HTML-pages/files with inline styles. This is very useful when you're sending emails.

17 237 154 2 772

Symfony mechanism for exploring and dumping PHP variables

41 784 349 2 735

Symfony Translation Component

58 498 146 2 518

The Symfony PHP framework

30 397 901 17 343

Symfony Routing Component

50 790 754 2 613

Symfony Process Component

67 288 804 2 687

Symfony polyfill for the Mbstring extension

76 622 614 2 740

Symfony HttpKernel Component

52 542 410 2 705

Symfony HttpFoundation Component

56 994 438 2 907

Symfony Finder Component

68 385 778 2 767

Symfony EventDispatcher Component

83 414 326 2 464

Symfony Debug Component

68 363 063 2 680

Symfony CssSelector Component

50 715 212 2 232

Symfony Console Component

82 410 324 3 262

A simple PHP Web Scraper

github.com/FriendsOfPHP/Goutte

Homepage

Source

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Installs : 11 024 490

The research objectives of Drug Delivery and Disposition are focused on enhancing drug bioavailability of dosage forms for extravascular administration using pharmaceutical-technological approaches (new drug formulations and process technology) as well as biopharmaceutical strategies (based on knowledge of mechanisms underlying drug absorption and hepatobiliary disposition). Significant contributions have been made in the understanding of the physicochemical principles behind formulation strategies for poorly soluble drugs like amorphous solid dispersions, nanoparticles, and mesoporous drug loaded silica. The Laboratory innovates in the development of preclinical models for ADMETox profiling; these model systems include in situ intestinal perfusion in mice (enabling the use of KO and humanized mice in intestinal absorption studies) and hepatocyte-based prediction of drug-induced cholestasis.

Pieter Annaert Patrick Augustijns Thomas Bouillon Guy Van den Mooter

Intestinal drug disposition – Biopharmaceutics

Drug Delivery and Disposition has a strong track record in the biorelevant profiling of intestinal drug absorption, covering all underlying processes including dissolution, precipitation, degradation and permeation. For this purpose, a wide range of simulation models is available, including the in vitro Caco-2 cell culture system, the Ussing chamber system and the in situ intestinal perfusion system. In addition, Drug Delivery and Disposition is able and licensed to perform whole animal absorption and pharmacokinetic experiments. Physiology-based pharmacokinetic modelling (Simcyp® Simulator) is available to extrapolate experimental data to human pharmacokinetics. One of the major targets involves the biorelevant and predictive evaluation of absorption-enabling strategies, including solubilization and supersaturation of poorly soluble drugs. In this respect, Drug Delivery and Disposition has elaborated a ground-breaking approach for evaluating intraluminal drug and formulation behavior in humans, involving the aspiration and characterization of gastrointestinal fluids. All absorption studies are supported by well-developed analytical equipment (LC-UV, -fluo, -MS/MS) to assess concentrations of drugs, excipients and endogenous compounds in biological matrices.

Hepatic drug disposition and drug-induced liver injury

In the field of hepatobiliary drug disposition and drug-drug interaction assessment, drug delivery and disposition has implemented the full spectrum of non-clinical model systems of the liver including: rat/human liver microsomes, rat/human hepatocytes in suspension, sandwich-cultured hepatocytes, cell lines transfected with hepatic drug transporters, isolated perfused rat liver and in vivo. Isolation and cryopreservation of plateablerodent hepatocytes and preparation of liver subcellular fractions is performed in-house. The research group has characterized several fluorescent transporter probes for evaluation and live imaging (by confocal microscopy) of drug transport processes in hepatocytes. Drug clearance prediction in special populations (e.g. pediatric), transporter-based pharmacokinetic boosting and liver unbound concentration assessment form major research objectives. The group has also developed and validated a holistic, hepatocyte-based in vitro model for identification of drug candidates showing risk for drug-induced cholestasis . The model has been mechanistically validated by bile acid profiling in sandwich-cultured hepatocytes. Computational expertise includes in vitro-in vivo extrapolation (IVIVE) algorithms for clearance prediction (SimCYP, R), compartmental and non-compartmental pharmacokinetic data analysis, as well as population pharmacokinetic analysis (NONMEM) of clinical exposure data. The group has taken the lead in generation of large in vitro transporter inhibition data sets leading to in silico models for structure-based prediction of transporter inhibition . Bioanalytical activities include LC-UV/FLUO/MSMS for preclinical and clinical samples.

A good educational system should have three purposes: provide all who want to learn with access to available resources at any time in their lives; empower all who want to share what they know to find those who want to learn it from them; and, finally, furnish all who want to present an issue to the public with the opportunity to make their challenge known.”
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